NeuroBiology & Genetics Group

Faculty of Medicine & Health Sciences, Universiti Putra Malaysia

RESEARCH

Total Funding Obtained (to date): RM1,753,080
Ongoing Projects
2017-2018
Putra Grant (IPS), UPM - RM20,000
Title: Identification and validation of a novel human orthologue for miR-3099 known as mds-21. PI: Dr. Michael KH Ling (Postgraduate: Mr. Shahidee Zainal Abidin)

2015-2017

Sciencefund, MOSTI - RM293,523
Title: TargetingJAK-STAT signaling pathwayto revertneurogenic-to-gliogenic shift in the brain of Ts1Cje Mouse Model for Down syndrome. PI: Dr. Michael KH Ling

Completed Projects
2015-2017
Fundamental Research Grant Scheme, MOHE - RM139,000
Role of the JAK-STAT signaling pathway during neurogenic-to-gliogenic shift in the brain of Ts1Cje Mouse Model for Down syndrome. PI: Dr. Pike-See Cheah

2014-2016

Putra Grant (Interdisciplinary), UPM - RM273,100
Psychosocial risk factors, BDNF and DAT1 Polymorphism and Risk of Major Depressive Disorder. PI: Joint between Prof. Dr. Normala Ibrahim with Dr. Michael KH Ling

2015-2016

Putra Grant (Postgraduate), UPM - RM15,000
Protein and gene expression profile of skeletal muscles in Ts1Cje Mouse Model of Down Syndrome : an insight to muscle weakness. PI: Dr. Pike-See Cheah (Postgraduate: Mr. Usman Bala)

2013-2015

Putra Grant, UPM - RM198,963
Molecular, metabolic and functional characterization of adult skeletal muscle in Down syndrome mouse model : insights into the muscle weakness seen in human condition. PI: Dr. Pike-See Cheah

2012-2015
Putra Grant, UPM - RM176,994
Identification of molecular mechanism responsible for hypotonia in adult Ts1Cje mouse model of Down syndrome. PI: Dr. Michael KH Ling

2013-2015
Putra Grant (Postgraduate), UPM - RM15,000
The association of CDKL5 and STXBP1 gene mutations in paediatric patients with early-onset epileptic encephalopathy in Malaysia. PI: Dr. Michael KH Ling (Postgraduate: Ms Ameerah Jaafar)

2012-2015
ERGS, MOHE - RM119,000
In vivo analysis of a novel miRNA, M1181, during mouse cerebral corticogenesis using in utero electroporation (IUE) approach. PI: Dr. Pike-See Cheah

2012-2015
FRGS, MOHE - RM81,000

A mouse embryonic stem cell culture system with stable and regulatable expression for a novel microRNA, miR3099: An in vitro approach towards functional genomics study. PI: Dr. Michael KH Ling

2013-2015
RUGS (Postgraduate), UPM - RM10,000

Expression profiling of a novel microRNA, miR3099, during neuronal development using an in vitro system. PI: Dr. Michael KH Ling (Postgraduate: Mr. Wei-Hong Siew)

2012-2014
Sciencefund, MOSTI - RM263,500

Establishment of the first 'superelectroporator' platform in Malaysia for the delivery of bicistronic expression vectors with shRNA and GFP open reading frames into the cerebral cortex of mouse model for Down syndrome. PI: Dr. Pike-See Cheah

2011-2013

RUGS, UPM - RM168,000

The identification of disrupted molecular networks involved in brain maturation and function in the Ts1Cje mouse model of Down Syndrome. PI: Dr. Pike-See Cheah